Now it's her mugshot showing a more haggard actress with smeared eye liner and bags under her eyes that has Kelly in the headlines and the Internet abuzz with comments. With many of those comments alleging drug abuse and worse, the actress is speaking out to defend herself.
"Absolutely not," Kelly told ABC News when asked if she is on drugs. "There is nothing I was on or abusing at the time."
"My poor mother has to see that picture," she said of her now infamous mugshot. "That's not what I look like. That's not me."
Kelly, 42, was taken into custody at 12:50 a.m. on Saturday by the Los Angeles County Sheriff's Department after her ex-boyfriend, John Michas, went to police to file a complaint, according to the Los Angeles County Sheriff's Office.
Released after posting $50,000 bail, Kelly says the allegations are false and that she was the one who was "roughed up" by Michas.
"Absolutely not," Kelly said when asked if she had assaulted Michas.
In 2010, Kelly had another mug-shot photo op after being arrested for driving while intoxicated - a charge to which she pleaded guilty. She was sentenced to 12 months of unsupervised probation and ordered to pay a fine, according to TMZ.
While the acting careers of stars like Topher Grace, Ashton Kutcher and Mila Kunis were launched by "The '70s Show," Kelly says her fall from TV sitcom stardom was the result of a devastating loss.
"I had lost a baby," she said. "As a result of that I lost it. I lost everything and I was abusing alcohol."
Kelly, who played Laurie, the promiscuous and slightly evil older sister to the show's main character, Eric Foreman, played by Grace, left the hit sitcom in 2003, when the show was at the height of its popularity. She was brought back on by producers for a few episodes at the end of the fifth season but was replaced at the beginning of the sixth.
"With 'That '70s Show' I was guilty of a drinking problem," she said. "And I ran."
Kelly had a brief stint in a comedy short in 2005 but has not done much acting since. She told ABC News that she has been sober for three months and says she is now ready for a comeback.
"I am not running from this," Kelly said. "I have paid my dues and if I can make it through this I can make it through anything."
ABC News' Lauren Effron contributed to this report.