Responding to a question from a reporter Monday, he said "I have a crisis at home? No, I think the press has a crisis. We, we are fine. My wife and I are, are fine. We take a temporary separation, but the press, it gives you stuff to write about."
Douglas was in Berlin promoting his latest film "Behind the Candelabra," in which he plays Liberace.
Last week, reps for the two actors said in a statement that they were "taking some time apart to evaluate and work on their marriage."
Douglas, 68, and Zeta-Jones, 43, were married in 2000 and have two children. For 13 years they've led a glamorous life and helped each other through their health crises.
In 2011, Zeta-Jones, who won an Academy Award for "Chicago," announced that she suffered from bi-polar disorder.
In 2010, Douglas, a two-time Academy Award winner whose films include "Wall Street" and "Fatal Attraction," battled throat cancer. He made headlines this summer when he spoke out about oral sex being a potential cause.
"It's undeniable that his throat cancer and her bi-polar disorder created a perfect storm of tension and issues that were really hard to overcome," Peter Castro, deputy editor for People, told ABC News.
"He gave very candid interviews about his sexual past that she really bristled at," Castro added. "She was not happy about his comments and that sort of got the ball rolling in terms of the split."