Question: What is the role of genetics in determining cholesterol levels?
Answer: You know, as I've practiced medicine in the clinic and I've put people on the same diet, I see a large amount of variability in terms of how much cholesterol lowering occurs. We've now identified a series of genes that predict how well you respond to dietary cholesterol restriction, saturated fat restriction, the other things we do with our lifestyle to modify risk.
So yes, genetics do play a role in what your cholesterol levels are. We don't have that completely understood, but perhaps within the next decade or two, we're going to have genetic profiles that are capably accomplished in the office of your physician to predict how well you respond.