Arias, 32, eventually admitted that she killed her ex-boyfriend Travis Alexander, but insists it was in self defense because he was an abusive and sexually deviant lover.
Anthony, now 25, insisted her daughter Caylee had been stolen by a nanny and didn't drop that story until the first day of her murder trial when she said the toddler drowned in a backyard pool. Anthony said she had become accustomed to lying to hide alleged sexual abuse by her father for much of her life.
Both women lied about their jobs, sought out sex immediately after the deaths, and even had similar hair styles.
Anthony was found innocent by a jury in 2011, while Arias is still on trial and could face the death penalty if found guilty.
Nancy Grace, a legal analyst for ABC News, says the Arias trial is also similar to Scott Peterson's murder of his wife Laci, who was eight months pregnant when she was killed in 2002. Peterson was having an affair with a masseuse at the time of his wife's death. Key Players and Key Evidence in Jodi Arias Trial
"The obvious one is that all three of them killed the one they professed to love the most...their love object, the thing they held dearest," said Grace, who has covered all three trials on her TV show.
"You also have of course the promiscuity, a very obvious (similarity)," Grace said. "You could argue all three were sexually driven murders. 'Tot Mom' [Grace's nickname for Casey Anthony] clearly wanted a wild carefree single life. She was dancing in a push-up bra and go-go boots while her daughter's body was rotting. She's going from one man's arms to another man's arms."
"Scott Peterson was a dog, there's no other way I can put it. And then Jodi Arias, who went from slashing the throat of her lover to literally hopping on top of another guy within a few hours," Grace said.
Ryan Burns testified that the day after Arias killed Alexander, he had a date with Arias and she laid on top of him and began kissing him.
"It could also be argued that all three are physically attractive," Grace said, "though I find none of them attractive. But all three use their looks and their charisma."
Each of the three changed their looks, dying their hair different colors and drastically changing their appearances for court. Grace was particularly struck by the similarity of Arias' and Anthony's hair style.
"With Arias coming in like 'Tot Mom' with the long hair draping their faces. If I sat 'Cousin It' at the table I don't think anyone would notice," the commentator said.
Grace claimed that none of the defendants looked at their juries. "They all sit in a position where their lawyers are kind of shielding them," she said.
There are other similarities. Anthony claimed falsely to work at Universal Studios while Arias told friends falsely that she worked at a Margaritaville bar.
Anthony said her daughter was taken by a fictitious nanny while Peterson said he wife was the victim of a Satanic cult. At one point Arias said she was present when a man and woman entered Alexander's apartment and killed him.