Aspartame, also found in NutraSweet and Equal, has been a source of controversy, even though studies have yet to link the artificial sweetener to negative health effects in humans. Even so, Pepsi says it was responding to consumers' concerns by deciding to move to a less controversial artificial sweetener. But some customers are tweeting that they don't like the new taste.
A spokeswoman for PepsiCo declined to comment to ABC News and referred to Nooyi's comments.
Here are some other times when a soda company's bet on something new didn't quite hit a sweet note.
Longtime Coca-Cola adviser Harold Burson recalls in a Coca-Cola video that testing showed consumers preferred the new taste before the launch, but company execs didn't realize consumers had an emotional bond to the original formula. Burson said then-CEO Roberto Goizueta called him into his office and said the company was going to create a new Coca-Cola formula.
"You could either change a product or you could change the marketing," Burson said in the video. "I think the thing that influenced Roberto the most was he was a chemical engineer and he was in charge of the technology. And so just like a carpenter thinks a hammer and nail is the solution to every problem, you know, I think you jiggle a formula and that's the solution to that problem. And I think that's what drove him."
"To hear some tell it, April 23, 1985, was a day that will live in marketing infamy," states an article on Coca-Cola's website. "On that day, The Coca-Cola Company took arguably the biggest risk in consumer goods history, announcing that it was changing the formula for the world's most popular soft drink, and spawning consumer angst the likes of which no business has ever seen."
Despite its short-lived life, a fan movement has grown recently to bring back Crystal Pepsi, including crowd-funding petitions with the hashtag #BringBackCrystalPEPSI.
A spokeswoman for PepsiCo told ABC News today, "There is no news on Crystal Pepsi at this time. While there are some rumors about our plans out there we have not confirmed anything and have nothing to say on it at this time."
Jones Soda's Thanksgiving Dinner
In 2004, Jones Soda sold limited-edition holiday beverages inspired by Thanksgiving dinner and donated a portion of the proceeds to charity. The flavors were: Green Bean casserole, Mashed Potato and Butter, Cranberry, and Turkey and Gravy Soda.
Available from 2003, Sprite Remix was one of the Coca-Cola Company's forays into flavoring, with "Berryclear," "Aruba Jam" and "Tropical." Though the drinks developed a following with some customers, the company discontinued the line in 2005.