Benchmarks in Tokyo, Shanghai and Australia declined while South Korea advanced.
U.S. stocks fell Tuesday after another slide in bond yields and a mixed batch of corporate earnings. Financial sector stocks led the declines.
Investors looked ahead to the Fed's release Wednesday of notes from its policymaking meeting last month and a speech Friday by chairman Jerome Powell.
Markets have "entered a holding pattern" ahead of Powell's speech at an annual gathering in Jackson Hole, Wyoming, said Jeffrey Halley of Oanda in a report.
Investors expect Powell to signal the Fed "is about to embark on a reinvigorated wave of easing," said Halley. However, he said U.S. data "simply does not support the need for an aggressive easing cycle."
The Shanghai Composite Index lost 0.1% to 2,875.63 and Tokyo's Nikkei 225 shed 0.4% to 20,597.21. Hong Kong's Hang Seng declined 0.3% to 26,161.92.
Seoul's Kospi gained 0.2% to 1,965.02 while Sydney's S&P-ASX 200 fell 1% to 6,477.60. Taiwan and Indonesian markets advanced while New Zealand and Singapore retreated.
On Wall Street, the benchmark Standard & Poor's 500 index snapped a three-day winning streak and fell 0.8% to 2,900.51. The Dow Jones Industrial Average slid 0.7% to 25,962.44. The Nasdaq composite dropped 0.7% to 7,948.56.
The U.S. market has been volatile this month as investors try to parse conflicting signals on the U.S. economy and determine whether a recession is on the horizon. A key concern is that the U.S.-Chinese tariff war will weigh on global economic growth.
Some chipmakers rose on Monday that the Trump administration delayed enforcement of export curbs on sales of U.S. technology Chinese telecom equipment maker Huawei Technologies Ltd. Qualcomm added 1.6%.
Last week, many stock indexes around the world hit their lowest points of the year before rallying. Analysts say the concerns that drove that sell-off could resurface at any time.
ENERGY: Benchmark U.S. crude gained 18 cents to $56.31 per barrel in electronic trading on the New York Mercantile Exchange. The contract shed 1 cent on Tuesday to close at $56.13. Brent crude, used to price international oils, rose 24 cents to $60.27 per barrel in London. The contract advanced 27 cents the previous session to $60.03.
CURRENCY: The dollar gained to 106.46 yen from Tuesday's 106.22. The euro was little-changed at $1.1099.