After six days of deliberation, the Pennsylvania jury were unable to render a unanimous verdict on any of the three counts of felony aggravated indecent assault with which Cosby had been charged.
"How do I describe the district attorney? Heinously and exploitively ambitious," her statement began. "How do I describe the judge? Overtly and arrogantly collaborating with the district attorney. How do I describe the counsels for the accusers? Totally unethical."
Cosby continued in her statement: "How do I describe many, but not all, general media? Blatantly vicious entities that continually disseminated intentional omissions of truths for the primary purpose of greedily selling sensationalism at the expense of a human life."
The 73-year-old philanthropist, who's been married to "The Cosby Show" creator since 1964, added that "historically, people have challenged injustices."
Cosby then said she was "grateful to any of the jurors who tenaciously fought to review the evidence; which is the rightful way to make a sound decision."
She added that his trial ending this way was a "manifestation of justice, based on facts, not lies."
She also thanked her husband's attorneys "for their hard work" along with her staff "for their continuous commitment to our family and me."
Cosby ended her statement by thanking her family, friends and supporters "who never gave up on us, despite it all."
Celebrities are also reacting to Bill Cosby's sexual assault case ending in a mistrial.
"Bill Cosby's trial is about much more than Bill Cosby. When women see justice served, their own fear & trauma are eased. When they don't...," she began.
Dunham continued, "Survivors of sexual assault have to watch every day as the legal system calls them liars and denies their truth. It is an unimaginable grind. My heart is with every survivor reliving the erasure of their own experience today. I see you. I love you."
Comedian D.L. Hughley wrote on Twitter: "A jury deliberated longer in the #Cosby Case! Than the murder of #PhilandoCastile!"
Actor Don Cheadle tweeted a cryptic reaction, referencing the "Fat Albert" theme song. He later added it was a "dark, commentary on all of it," when one user asked what he meant by it.
"Silicon Valley" star Kumail Nanjiani wrote, "Serious question: How will Cosby ever get an unbiased jury? Who doesn't know him or have some sort of association with him?"
RuPal took to Twitter to write, "Our criminal justice system is a joke that’s not at all funny."