"You’re somebody that everybody’s always rooting for, and I don’t know if you know that or feel that -- because there are people that not everybody’s rooting for," Handler said referring to Barrymore's divorce, which was announced in April. "But you are somebody who everybody goes, ‘Oh, no. No.’ You want good things to happen to you. So do you feel that?"
"I can’t tell you how incredible it was to feel because I put in my statement about divorce the word ‘failure,’ because it’s so honest," Barrymore responded. "You break up with somebody, and you’re just like, ‘Yeah, that didn’t work.’ And you get divorced and you’re like, ‘I’m the biggest failure. This is the biggest failure.’ It's so shameful and hard to actually go through that, even privately."
The 41-year-old "Blended" star told Handler she's getting through it with the help of friends and family.
"Everyone has just been so cool and chill and nice about everything that it quelled my own fears and demons about how we sort of have to go through things in life," she said.
And while she's not ready to date quite yet, she is looking forward to some girlfriend time.
"The biggest sort of path in my life has been paved by women," said the mother of two daughters. "I love women."
Barrymore and Kopelman released a joint statement in April announcing the end of their four-year marriage.
"Sadly our family is separating legally, although we do not feel this takes away from us being a family," the pair said in the statement. "Divorce might make one feel like a failure, but eventually you start to find grace in the idea that life goes on. Our children are our universe, and we look forward to living the rest of our lives with them as the first priority."