George Clooney and Girlfriend Elisabeth Canalis Split

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George Clooney and relationships. He just can't seem to find one he likes.

The actor and his girlfriend of two years, Italian actress Elisabetta Canalis, announced their breakup today.

"We are not together anymore," they said in a statement to emailed by Clooney's publicist. "It's very difficult and very personal, and we hope everyone can respect our privacy."

One week ago, Clooney, 50, and Canalis, 32, seemed smitten, sharing a candlelit dinner at a restaurant near the actor's home on Italy's Lake Como. Canalis recently told the Italian magazine Chi that her relationship with Clooney was stronger than ever and hinted that marriage might be in the cards.

"I am a firm believer in marriage. In the future I will be married," she said. "But for the time being I am as happy as I am, I don't need anything to confirm how happy I am."

For Clooney, though, wedded bliss isn't all that blissful. After his 4-year-long marriage to Talia Balsam, in 1995, he famously told ABC News' Barbara Walters that he'll never marry again. He's had a hard time living down that statement, despite the fact that he hasn't talked extensively about his personal life in more than a decade. (In 2007, Michelle Pfeiffer said she bet him $100,000 that he'll walk down the aisle again.)

Women seem to have taken a backburner to the Oscar-winner's acting and philanthropic ambitions. Since his 1993 divorce, he's dated British model Lisa Snowdon, cocktail waitress/reality TV personality Sarah Larson (who was the first woman he brought to the Oscars), and most recently, Canalis.

While his love life may be floundering, Clooney's career is hotter than ever. His latest film,"The Ides of March," which he wrote, directed and stars in, will be the opening movie at August's 2011 Venice film festival. No word yet on who'll be on his arm for that event.