After stepping up to the podium to give her 5-word acceptance speech, which is a Webby tradition, she had some choice words about her Instagram past.
"Nude selfies till I die," she said to a round of applause.
But West, 35, wasn't the only highlight of the night.
Lena Dunham was also honored and as she accepted her award, the whole room sang "Happy Birthday" (Dunham turned 30 last week).
The creators of "Making a Murderer," Laura Ricciardi and Moira Demos, also took home a Webby. "The story is not over," they said, teasing a possible season 2 of the hit Netflix series.
Finally, the night ended with soul singer Erykah Badu paying homage to her friend Prince, who died last month at the age of 57.
She sang one of her favorite Prince songs to close the show.