During an online question-and-answer session Saturday, the 56-year-old singer was asked whether Drake, 28, was a good kisser.
"You asked the million-dollar question," she responded. "I kissed a girl, and I liked it."
When another fan asked what advice Madonna would give her younger self, knowing what she knows now, the singer replied, "Don't kiss Drake, no matter how many times he begs you to."
After the kiss, which took place while Drake was seated onstage, he responded by leaning forward and covering his mouth.
"Don't misinterpret my shock!! he explained in an Instagram post the next day. "I got to make out with the queen Madonna and I feel  about that forever. Thank you @Madonna."