"I could not have had the life or the career in the way that I had it if I'd chosen to have children," the 60-year-old media mogul told Walters in an interview for the upcoming ABC News special, "Barbara Walters Presents: The 10 Most Fascinating People of 2014."
Winfrey, who ended her talk show in 2011, also said she doesn't miss having to do a show every day.
"I don't miss that because you know you're only as good as the last show. You're always chasing the numbers," Winfrey said. "And this is the thing: The 25 years are a blur to me because I just worked."
And Winfrey has continued to work. This year, she crisscrossed the country on an inspirational tour, published the book "What I Know For Sure," and led her cable network OWN to record numbers of viewers. She also produced and acted in the movie "Selma," which opens in New York City and Los Angeles on December 25 and nation-wide on January 9, 2015.
Winfrey says she's been enjoying life more since her show ended. "For example, I'm going to do something I've always wanted to do. I wanted to do that truffle hunt, with the pigs and the dogs. So, I'm at least taking some time," said Winfrey.
"As we grow together, as we get older together, he becomes a more affirming and more loving part of my life than he's ever been," Winfrey said.