May 10, 2013— -- intro: Sorry, "Vampire Diaries" fans: ABC News has confirmed that after several years of dating, co-stars Nina Dobrev and Ian Somerhalder have called it quits. So, will their personal lives affect life on the CW set? No, an insider tells Us Weekly. "[They're] consummate professionals... [and] will continue to work together and remain best friends."
They're not alone: Here are other famous exes who worked together post-break up.
quicklist: 1title: Blake Lively and Penn Badgleytext: Their "Gossip Girl" alter egos may have ended up together, but Blake Lively's real-life romance with Penn Badgley wasn't meant to be. In 2010, they ended their relationship of more than two years, and since then, both have moved on: Lively is married to actor Ryan Reynolds, and Badgley is dating actress Zoë Kravitz.
quicklist: 2title: Jennifer Lopez and Marc Anthony text: After seven years and two children, Jennifer Lopez and Marc Anthony ended their marriage--but not their professional relationship. Ten months after announcing their split, the exes reunited for their ¡Q'Viva! The Chosen show in Las Vegas. Lopez is currently dating dancer Casper Smart.
quicklist: 3title: Sophia Bush and Chad Michael Murray text: In 2005, Chad Michael Murray and Sophia Bush, who met on the set of "One Tree Hill," were married. It didn't last long: they separated five months later. While some may have thought that Murray's engagement to crew member Kenzie Dalton the next year might have been awkward for Bush, "She's moved on," her pal told People magazine. "They have a professional relationship."
quicklist: 4title: Justin Timberlake and Cameron Diaztext: Justin Timberlake and Cameron Diaz ended their nearly four-year relationship in 2007--and three years later, reunited to film the movie, "Bad Teacher." It "really wasn't a big deal," Diaz said at the time. "We had a great time!" Timberlake is now married to actress Jessica Biel.
quicklist: 4title: Drew Barrymore and Luke Wilson text: Drew Barrymore and Luke Wilson, co-stars in the 1998 film "Home Fries," dated from 1996-1998, but stayed friendly afterwards. In fact, Barrymore, who is now married to Will Kopelman, cast her ex in the 2000 blockbuster, "Charlie's Angels." "That's Drew," he told People at the time. "She didn't let the personal stuff get in the way."