O'Rourke will be part of "Oprah's SuperSoul Conversations from Times Square" on Feb. 5. He'll speak to Winfrey one-on-one as part of an event featuring others, including actors Bradley Cooper and Michael B. Jordan.
O'Rourke, 46, rose to national Democratic prominence while nearly unseating Republican Sen. Ted Cruz in deep red-Texas last November.
Despite other top Democrats taking steps to likely join the 2020 presidential race, O'Rourke's camp suggests he won't make up his mind for at least a few more weeks.
Winfrey herself has been the subject of 2020 chatter, but has said she doesn't plan to run.