2016 Presidential Hopefuls Ready to Face Off During 2nd GOP Debate

Donald Trump, Carly Fiorina, Ben Carson and other top Republicans candidates set for second debate at the Reagan Library in California.
4:09 | 09/16/15

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Transcript for 2016 Presidential Hopefuls Ready to Face Off During 2nd GOP Debate
downstream from where the vehicles came to rest. And debate. Donald Trump front and center taking fire from all sides, even vice president weighing in for the first time. The other candidates hoping for a breakout moment when they face off tonight at the Reagan library in California. ABC's Tom llahere. Good morning, Tom. Reporter: George, good morning to you, the debate will take place in a building behind me and this is holy ground for republicans, as you mentioned the Reagan library but where the 40th president is buried so they will take this seriously and those 11 candidates are going to be on stage fighting to prove they can carry the Reagan legacy, the Reagan tradition and center stage the front-runner, Donald Trump. Overnight, Donald Trump rallying on a battleship in southern California, supporters up close but right down below, demonstrators trying to drown him out. Trump giving them a thumb's up ignoring them in his speech and punching his immigration stance hard. A woman who is nine months pregnant walks across the border, has a baby and you have to take care of that baby for the next 85 years. Reporter: But now vice president Joe Biden saying enough is enough calling trump's message sick. There's one guy absolutely denigrating an entire group of peep, appealing to the baster side of human nature. Working on this notion of sen phobia if a way that hasn't occurred in a long time. Reporter: Biden's comment coming as conservative super pac S are unleashing anti-trump ads like this from right to rise which is supporting Jeb bush. ? We lose everywhere. Murderers, crime. Reporter: I asked trump about the predebate pile-on. It's not going to have any impact. Have you seen the ads? No energy. The whole deal is awful. Reporter: This as a new national poll shows Dr. Ben Carson neck and neck with trump as they head into the debate. Well, the nice hinge is I'll be center stage this time so it'll be more difficult for them to ignore me. Reporter: And trump who famously said he didn't prepare for the last debate may try a different strategy this time. How is your debate prep going? I think very good. Reporter: Now, we should note that this is a much smaller space, trump has fed off those large crowds, he feeds off their laugh, off their cheers but this is a much smaller space. It's not going to be like Cleveland where he was in front of thousands and each campaign will have seats there so it will be equal. Back to you. Tom, thanks very much. We break it down with Jon Karl. Last time around took tough questions from the moderators, the other candidates not so much but this time CNN signaling they'll try to create direct confrontations. The moderators are clear they want to provoke a fight so it's going to happen, not only that but the others will be guns for trump much last time, George, the other candidates felt they could ignore him. He would fade away. He would commit some gaffe that would kill his campaign. Nobody thinks that anymore. They will be going after him hard. Ben Carson joked about it. He was basically ignored except he had a great closing statement. This time will be a real test for him. Carson is the story. He is rising faster than trump. If you look at the latest poll, he is actually statistically tied with three survived and this morning, one is still missing. Also in Utah's Zion national park four hikers dead, three still missing after flash flooding swept through a canyon. We are hoping but right now it's not looking good. Remember, all those horrible pictures you just saw come from on inches of rain because they fall in mountains and all congregates at the top of the mountain and flash floods down. Especially when you have dry areas or burn scars and that's what we're about to see today. Great news for the valley fire, they'll actually get rain, so the Sacramento valley Wil pick up 1 to even 2 inches of rain. This is good and bad, bittersweet and we'll follow it throughout the day. Thanks very for president, "Your voice, your vote" and the tragedy on the way

This transcript has been automatically generated and may not be 100% accurate.

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