COVID updates: Secretary of Defense Lloyd Austin tests positive

Dr. Anthony Fauci strongly recommended against large New Year's Eve parties at Wednesday's White House briefing.

"Should you change or cancel your plans? If your plans are to go to a 40-50 person New Year's Eve party with all the bells and whistles and everybody hugging and kissing and wishing each other a happy new year, I would strongly recommend that this year, we do not do that," Fauci said. 

Fauci said "all indications point to a lesser severity of omicron versus delta." But he warned, "we should not become complacent since our hospital system could still be stressed in certain areas."

White House COVID-19 coordinator Jeff Zients said, "We have directly helped more than 30 states and territories by deploying over 2,100 federal personnel and thousands of ambulances, ventilators and other critical supplies."

Supplies include gloves, masks, respirators and face shields, he said.

He added, "More than 13,000 National Guard members have been activated in 48 states to support the COVID response, from vaccinations, to testing, to clinical care."

At the briefing, CDC Director Rochelle Walensky defended the agency's shortened isolation guidelines.

"We do know the vast majority of viral transmission happens in those first five days, somewhere in the 85 to 90% range. So if a person can isolate for the first five days they absolutely should," she said. "We also don't know that antigen tests give a good indication of transmissibility at this stage of infection. On the other hand, we know that after five days people are much less likely to transmit the virus and that masking further reduces that risk. And this is why people need to mask for five days after the five days of isolation."

After five days, asymptomatic people with COVID-19 can leave isolation, but must wear masks around others, according to the new guidelines.

-ABC News' Cheyenne Haslett

Omicron and delta are twin threats driving up cases to record numbers and leading to spikes in hospitalizations and deaths, WHO Director-General Dr. Tedros Adhanom Ghebreyesus said at a news conference Wednesday.

"I am highly concerned that omicron being more transmissible, circulating at the same time as delta, is leading to a tsunami of cases," Tedros said.

As the pandemic drags on, it's possible that new variants could become resistant to current vaccines, necessitating vaccine adaptations, he warned.

He added, "While 2021 has been hard, I ask everyone to make a New Year’s resolution to get behind the campaign to vaccinate 70% by the middle of 2022."

-ABC News' Christine Theodorou

More than 84,000 Americans are currently hospitalized with COVID-19 -- a 40,000 jump over the last seven weeks, according to federal data.

In the last month, federal data shows the nation's daily case average has nearly tripled.

A soaring demand for tests and a backlog of holiday reporting drove Monday's case total to 440,000 -- the nation's highest one-day total ever, according to federal data.

While this high reflects the latest omicron surge, it's also very likely skewed due to a backlog in reporting over the Christmas weekend and an increase in demand for tests.

-ABC News' Arielle Mitropoulos

The FDA and CDC could decide on boosters for children ages 12 to 15 in "the days to weeks ahead," CDC Director Rochelle Walensky told CNN's "New Day" Wednesday.

The CDC authorized the Pfizer vaccine for 12- to 15-year-olds on May 12, meaning some of those kids are now over six months past their second dose, which was when boosters were recommended for adults.

Walensky also noted that vaccine manufacturers are working to acquire data for children under the age of five, but an authorization "will not be in the month ahead."

-ABC News' Arielle Mitropoulos