Some of the highest death tolls are in Texas, Georgia and North Carolina.
The United States is facing a COVID-19 surge this summer as the more contagious delta variant spreads.
More than 672,000 Americans have died from COVID-19 while over 4.6 million people have died from the disease worldwide, according to real-time data compiled by the Center for Systems Science and Engineering at Johns Hopkins University.
Just 63.6% of Americans ages 12 and up are fully vaccinated against COVID-19, according to data from the Centers for Disease Control and Prevention.
Los Angeles County will require vaccination or proof of a negative test for events with more than 10,000 people, including clubs, concerts and sporting events.
As of Tuesday, LA County had 1,224 COVID-19 patients in hospitals.
In New York state, masks are now required at child care centers for children ages 2 and above and for all staff and visitors, Gov. Kathy Hochul said in a tweet Wednesday.
"These universal mask requirements apply to anyone medically able to tolerate wearing a mask, regardless of vaccination status," the governor said.
"With Delta on the rise, requiring masks is a key part of slowing the spread, reopening our economy safely, and protecting vulnerable New Yorkers," Hochul tweeted. "This new mask requirement ensures that children in our child care facilities receive the same protection as children in our schools."
Talk show host Wendy Williams has a breakthrough COVID-19 case, her show said.
The new season of "The Wendy Williams Show" will be postponed to Oct. 4.
New data from Pfizer show that Americans will likely need a booster shot about six months after their second vaccine dose.
Pfizer said the vaccine's protection against infection is waning over time. The company, however, said it didn't find significant evidence that the delta variant was contributing, more that it would've happened over time regardless.
Pfizer also heavily leaned on data from Israel to show that the vaccine's protection against severe COVID-19 could start to erode in the U.S. as it has there. So far, vaccine efficacy against hospitalization in the U.S. has held up, according to CDC data.
The data was released by the FDA ahead of a meeting where it will be reviewed by independent advisers. If the advisory committee supports boosters, the FDA would then formally amend its vaccine approval for Pfizer. The decision will be sent to the CDC's Advisory Committee on Immunization Practices and finally to the CDC for sign off.
-ABC News' Cheyenne Haslett
