The Monday night blaze burned Sweet Dirt Inc. in Eliot. The facility is a state-licensed organic cannabis grower.
The Portsmouth Herald reports Eliot Fire Chief Jay Muzeroll said wind in the area mitigated the possibility of a contact high for people in the area.
Muzeroll says the building was substantially damaged. There were no fire hydrants in the immediate area. No one was in the facility when the fire started, and no one was hurt.
The cause of the fire wasn't immediately clear Tuesday. The business is owned by a local couple and employs more than a dozen people.