UK gears up for huge vaccination plan watched by the world

Shipments of the coronavirus vaccine developed by American drugmaker Pfizer and Germany’s BioNTech have been delivered in the U.K. in super-cold containers

LONDON -- Shipments of the coronavirus vaccine developed by American drugmaker Pfizer and Germany’s BioNTech were delivered Sunday in the U.K. in super-cold containers, two days before it goes public in an immunization program that is being closely watched around the world.

Around 800,000 doses of the vaccine were expected to be in place for the start of the immunization program on Tuesday, a day that Health Secretary Matt Hancock has reportedly dubbed as “V-Day,” a nod to triumphs in World War II.

“To know that they are here, and we are amongst the first in the country to actually receive the vaccine and therefore the first in the world, is just amazing,” said Louise Coughlan, joint chief pharmacist at Croydon Health Services NHS Trust, just south of London.

“I'm so proud," she said after the trust, which runs Croydon University Hospital, took delivery of the vaccine.

Last week, the U.K. became the first country to authorize the Pfizer-BioNtech vaccine for emergency use. In trials, the vaccine was shown to have around 95% efficacy. Vaccinations will be administered starting Tuesday at around 50 hospital hubs in England. Scotland, Wales and Northern Ireland will also begin their vaccination rollouts the same day.

Russia on Saturday began vaccinating thousands of doctors, teachers and others at dozens of centers in Moscow with its Russian-made Sputnik V vaccine, which was approved over the summer after being tested in only a few dozen people.

The excitement in Britain, which has Europe's highest virus-related death toll at more than 61,000, was palpable.

“Despite the huge complexities, hospitals will kickstart the first phase of the largest scale vaccination campaign in our country’s history from Tuesday,” said Professor Stephen Powis, NHS England’s national medical director.

Patients aged 80 and above who are already attending hospitals as outpatients and those being discharged after a stay in the hospital will be among the first to receive the jab. Hospitals will also start inviting over 80s in for a vaccine shot and will work with nursing homes to book staff into vaccination clinics. Any appointments not taken up will be offered to those health workers deemed to be at the highest risk of COVID-19. Everyone who is vaccinated will need a booster jab 21 days later.

“Our goal is totally to protect every member of the population, Her Majesty, of course, as well,” Dr. June Raine, chief executive of Britain's Medicines and Healthcare products Regulatory Agency, which authorized the vaccine, told the BBC.

Now that the first tranche of the vaccine has arrived from Pfizer's manufacturing plant in Belgium, checks are being conducted by a specialist medical logistics company to ensure there was no damage in transit. This could take up to a day.

Each box containing the vaccines, which includes five packs of 975 doses, will need to be opened and unpacked manually at specially licensed sites. After that, the vaccines will then be made available to hospitals.

Delivering the Pfizer-BioNTech vaccine is complicated because it needs to be stored at super-chilled temperatures: about minus 70 degrees Celsius (minus 94 degrees Fahrenheit). Fortunately, the vaccine is stable at normal refrigerator temperatures, between 2 and 8 degrees Celsius (35.6 to 46.4 F), for a few days, meaning it can be stored locally. After defrosting the vaccine, which takes a few hours, additional time is required to prepare it to be given in a shot.

Public Health England has secured 58 special Twin Guard ultra-low temperature freezers that provide sufficient storage for approximately five million doses. The fridges, which are not portable, each hold around 86,000 doses.

There are plans for vaccination centers treating large numbers of patients in sports areas and conference centers and for local pharmacies to be able to offer the jabs as they do with annual influenza shots.

Although nursing home residents top the prioritization list given to the British government by the independent Joint Committee on Vaccination and Immunization, they won't be getting the vaccinations straight away, as the vaccine packs of 975 doses cannot yet be divided, making it very difficult to deliver vaccines to individual care homes.

The NHS hopes authorities will soon approve a safe way of splitting up the dose packs so the shots can get to nursing homes during December.

During the first phase of the immunization program, Britain has created nine separate groups in its prioritization list down to those aged 50 and above. Overall, it hopes that up to 99% of people most at risk of dying from COVID 19 will have been immunized during the first phase.

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