"I hope you know how grateful I am to all of you," Biden said.
Democrats kicked off their convention Monday with a who's who of guests who all touted Vice President Kamala Harris' run for the White House.
Several topics came up during the night including the future of reproductive rights and Project 2025.
Harris made a surprise appearance after several Democratic VIPS took the stage, including Rep. Alexandria Ocasio-Cortez.
The main stars of the night were some of the Democrats' longstanding figures including Secretary of State Hillary Clinton.
But the main spotlight came as President Joe Biden spoke to the cheering crowd, reflecting on his four years as president and his decision to "pass the torch" to Harris.
Biden had pointed words for Trump.
"Donald Trump calls America a failing nation. He says we're losing," Biden said. "He's the loser. He's dead wrong."
"America's winning, and the world's better off for it," Biden continued.
Biden took time to tout his administration's work on COVID, the economy and health care.
"Because of you, we've had one of the most extraordinary four years of progress ever, period. And when I say 'we,' I mean Kamala and me," Biden said.
Biden pointed to the recent agreement reached by the government and Medicare to lower the prices of 10 commonly used prescription drugs -- a result of the Inflation Reduction Act.
"And guess who cast the tie breaking vote? Vice President, soon to be President Kamala Harris," Biden said.
Biden reiterated his reasons for running for president in 2020 citing the Unite the Right rally in 2017 in Charlottesville, Virginia, as a turning point in the country.
"I ran with a deep conviction," he said.
"Because of all of you in this room and others, we came together in 2020 to save democracy," Biden added. "As your president, I've been determined to keep America moving forward, not going back. To stand against hate and violence in all its forms, to be a nation where we not only live with, but thrive on diversity," Biden added.
A protest banner was spotted in the crowd during Biden's remarks, reading, "Stop arming Israel."
Delegates appeared to be trying to cover it up with "We heart Joe" signs, but the banner was briefly visible in the back of the lower bowl before the lights were turned off in that section.
