Winston threw an interception that was returned for a touchdown on his first passing attempt against the Titans. The Buccaneers' rookie quarterback was picked off by Coty Sensabaugh, who returned it 26 yards to give Tennessee a 14-0 lead.
While Winston's NFL debut started in inauspicious fashion, Mariota was impressive on his first career series, orchestrating an 89-yard drive punctuated by his 52-yard touchdown pass to Kendall Wright.
Before his touchdown pass, Mariota threw a dart to Delanie Walker for a 22-yard gain on a third-and-10. On the next play, he faked a play-action handoff, and quickly threw a flat-footed pass to Wright, who outran multiple defenders for the touchdown.
Mariota threw another touchdown pass on Tennessee's second possession of the game, capping a six-play drive with a 12-yard scoring strike to Bishop Sankey to give the Titans a 21-0 lead.
ESPN Titans reporter Paul Kuharsky contributed to this report.