Getting his most extensive playing time of the season, Murray became the first player to score a rushing touchdown against the Chiefs this season when he bounced around the left side and scampered into the end zone from 11 yards out.
He later added a 90-yard touchdown run -- fourth-longest in franchise history and third-longest by a Raiders running back.
Murray, a sixth-round pick in 2013, who spent all of his rookie season on injured reserve with a foot injury, finished with 112 yards on four carries. He's the first Oakland running back to top the 100-yard mark since fullback Marcel Reece went for 123 against the New York Jets on Dec. 8, 2013.
He's also the first NFL player to run for at least 110 yards on fewer than five carries.
"The plan today was clearly to get him going," interim Raiders coach Tony Sparano said after the win. "We wanted to get him going early in the game and we did. Unfortunately we lost him."
Murray was taken to the Raiders' locker room late in the second quarter to be examined for a possible concussion. No official word was given on Murray's condition after halftime but the team announced he was not returning.
He left Oakland's locker room without talking to reporters, but his teammates were effusive in their praise of Murray, who has been third-string on the depth chart all season.
Quarterback Derek Carr gushed about the running back.
"My goodness, the guy did a great job," Carr said. "I'm trying to think of a lot of good things to say about him but there's too many. He gave us a spark, and it was really good."
The good news for Murray is that the Raiders have a nine-day break before playing at St. Louis. That gives him a few extra days to recover and pass the NFL-mandated concussion protocol.