On Monday, Rams coach Sean McVay said Henderson "felt his knee" during pregame drills.
"He felt a little something in his knee and that was kind of what led to Cam and Kyren getting the majority of the work," McVay said. "But he said he felt fine [Monday]."
Akers led the Rams in rushing during Sunday's game, but Williams had more snaps.
Henderson, a third-round pick in 2019 who was playing on the last season of his rookie contract, ran for 283 yards and three touchdowns on 70 carries this season for Los Angeles. He also had 17 catches for 102 yards.