Machado sprained his right knee while taking a swing against the Yankees on Aug. 11. He dropped in a heap in the batter's box and limped off the field, assisted by his manager and trainer.
Orioles manager Buck Showalter said before Friday's game against the Chicago Cubs that there probably will be updates on Machado in the next two days.
The 2013 Gold Glove winner is hitting .278 with 12 homers and 32 RBIs in 82 games. He missed the first month of the season while recovering from surgery on his left knee.
The Orioles lead the American League East by nine games and are 21 games over .500 entering Friday's play.
The Associated Press contributed to this report.