"He looked so much better than he did last year, the way he was moving," defensive end Jack Sawyer told reporters Tuesday in Columbus. "The only part of sports that I hate is injuries. I just feel so bad for him."
Pryor's injury leaves Ohio State with only three healthy scholarship running backs in Henderson, Williams and incoming freshman Dallan Hayden, an ESPN four-star recruit.
"Learning how to embrace the obstacles life may throw your way," Pryor tweeted Tuesday.
Rivals.com first reported Pryor's season-ending injury.
Pryor was ESPN's No. 7 running back and No. 128 overall player in the 2021 recruiting class.
Henderson last fall broke Maurice Clarett's school single-season freshman rushing record with 1,248 yards, averaging 6.8 yards per carry with 15 touchdowns. Williams had 508 yards and three touchdowns on only 71 carries.