Purdue football coach Jeff Brohm had a presumed positive test for the coronavirus on Sunday, the school announced.
Brohm, who is at home in isolation, is undergoing a PCR test to confirm the results of an antigen test.
The Boilermakers are scheduled to open their season Saturday at home against Iowa.
Brohm, 49, is entering his fourth season at Purdue with a record of 17-21. The former NFL and XFL quarterback is 47-31 overall as a college head coach.
ESPN's Adam Rittenberg contributed to this report.