Colts owner Jim Irsay said after Indianapolis' 27-14 loss that Hilton could miss some time because of the injury.
Hilton had seven catches for 88 yards before his injury. The team announced that he was getting an X-ray on his knee.
Hilton has had back-to-back 1,000-yard seasons, including a career-best 1,345 yards in 2014.
ESPN Colts reporter Mike Wells and The Associated Press contributed to this report.