-- intro: "This Week" is wrapping up 2014 with a special look back at the people who broke through and made a difference this year. Click through to see the 2014 "This Week" Game Changers.
quicklist: 1category: title: Political Womenurl: text: ABC News’ Jonathan Karl on the GOP women who took the midterms by storm, and the potential 2016 battle brewing between Hillary Clinton and Sen. Elizabeth Warren.
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quicklist: 2category: title: Overseas Adversariesurl: text: A new villain called the Islamic State in Iraq and Syria -- known as ISIS -- emerged with terrifying tactics, while remnants of the Cold War were reignited as Russian President Vladimir Putin expanded his influence into Ukraine.
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quicklist: 3category: title: Football: On and Off the Fieldurl: text: Football may mean different things around the world, but this year it consistently prompted intense interest. From World Cup soccer standouts like U.S. goalkeeper Tim Howard to the NFL and domestic violence scandals, football took center stage in 2014.
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quicklist: 4category: title: Ebola Heroesurl: text: Ebola has ravaged the world with fear and thousands of deaths. But through it all, heroes have emerged on the front lines to bring comfort and care to those who need it most.
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quicklist: 5 category: title: ALS Ice Bucket Challengeurl: text: From presidents to movie stars, this year social media was chock-full of videos showing people fulfilling the 24-hour challenge. By pouring a bucket of ice water over their heads, supporters around the world raised money and awareness for the neurodegenerative disease ALS, known as Lou Gehrig’s disease.
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quicklist: 6category: title: Marijuana Legalizationurl: text: Cannabis, Mary Jane, pot or weed - the name doesn’t matter. Marijuana legislation passed across the country in 2014, making it twenty-three states and the District of Columbia that allow either recreational or medicinal use.