"I set him down for two minutes and forgot about him, walked out," Neil Miller told ABC affiliate WLOS-TV.
"I was terrified," he said of discovering that Chuck, his 3-year-old Colombian red tail boa constrictor, was missing.
Hotel staff at the Rodeway Inn and Suites in Asheville, North Carolina, called the Buncombe County Animal Shelter for help Monday, the Asheville Police Department told ABC News today.
The housekeeper discovered the snake nestled partly beneath the sheet and atop the comforter, police said.
The animal shelter directed the call to the police, who responded to the snake before it was taken to the shelter.
Miller, who said he had been visiting a friend, showed up a few hours later to retrieve his "son," WLOS reported.
Miller picked up Chuck and lovingly carried him on his shoulders, saying the snake has a good temperament and he holds him often.
WLOS shared a video of the interaction:
There were no injuries and no charges filed, police said.
ABC News was unable to reach Miller and the Buncombe County Animal Shelter.