The search encompassed more than 7,400 square miles (19,000 square kilometers) over 192 hours since the capsized boat was reported Tuesday about 26 miles (42 kilometers) southeast of Key West.
The Coast Guard said in a news release that 13 people were rescued. The survivors said they left Cuba on Monday night with 22 people aboard.
Cubans intercepted at sea by the U.S. are generally returned to their home country.
“Our deepest condolences go out to the families and loved ones impacted by this tragedy,” said Sean Connett, command duty officer of the Coast Guard's 7th District. “The decision to suspend a search is always difficult and is made after exhausting all search information.”