DENVER -- Voters narrowly made Denver the first U.S. city to decriminalize psilocybin, the psychoactive ingredient in "magic mushrooms."
Final election results will be released on May 16, he said.
"I think today's outcome really demonstrates that the conversation is going to continue, and the world is ready for it," said Cindy Sovine, chief political strategist for the campaign to decriminalize the drug.
"Psychedelics are already here. Now we can start to have the conversation about using them mindfully," she added.
Organizers say their only goal in the mushroom measure is to keep people out of jail in Denver for using or possessing the drug to cope with depression, anxiety, post-traumatic stress and other conditions.
"We're not talking about legalization, we're talking about not putting people in jail," Sovine said.
The initiative effectively decriminalizes use or possession of psilocybin by people 21 and older, making it the lowest enforcement priority for police and prosecutors. It does not legalize psilocybin or permit its sale by cannabis businesses.
Kevin Matthews, director of the Decriminalize Denver campaign, said psilocybin has helped him deal with depression for years.
"This is not something you have to take every day," the 33-year-old Denver native said. "It provides a lot of lasting benefits, weeks and months after one experience."
Psilocybin has been federally outlawed since the 1960s, when it was widely known as a recreational drug. The ban stymied medical research, but small studies in recent years have found the substance had positive effects on anxiety and depression for cancer patients.
Users have described seeing vivid colors and geometric patterns and experiencing powerful spiritual connections and emotions.
Magic mushrooms have been used in religious practices for decades because of their powerful effect on perceptions and spiritual experiences. Those same effects have appealed to recreational users dating to the 1960s counterculture movement.
A California effort to decriminalize psilocybin failed to qualify for the statewide ballot in 2018. Organizers in Oregon are trying to gather enough support to put an initiative to a statewide vote next year.
It took the pro-psilocybin organizers in Denver three tries to develop language approved by city officials for the ballot. They collected more than 8,000 signatures to qualify for Tuesday's election.
Denver Mayor Michael Hancock and District Attorney Beth McCann opposed the initiative, but there was no organized campaign against decriminalization. The city's election largely focused on a six-way race for mayor and a heated effort to end Denver's "urban camping" ban that affects people without housing.
Voters roundly rejected an end to the camping ban. In the mayor's race, incumbent Michael Hancock will face a June 4 runoff election against challenger Jamie Giellis.
The mushroom ordinance also prevents city funds from being used to pursue criminal penalties on possession or use and creates a panel to study the effects of the change.
Associated Press writer Thomas Peipert contributed to this report.