Iran and the United States are preparing for a fifth round of negotiations over Tehran’s rapidly advancing nuclear program, with enrichment emerging as the key issue

Iran’s top diplomat is insisting that Tehran will never stop enriching uranium, further underlining the Islamic Republic’s red line in negotiations with the United States over its rapidly advancing nuclear program

The United States and Iran have held a series of "indirect" nuclear talks.

Iran has summoned a British diplomat to protest what it described as the “illegal and unjustified” detention of an Iranian in the U.K. Iran’s state-run IRNA news agency reported Sunday that the Foreign Ministry summoned the U.K. chargé d’affaires and c...

ABC News’ Jonathan Karl interviews U.S. Special Envoy to the Middle East Steve Witkoff on “This Week.”

President Donald Trump confirmed that Iran has the U.S. proposal for a nuclear deal but gave few details following his four-day Middle East tour.

Pres. Trump told reporters aboard Air Force One that the U.S. is inching closer to a nuclear deal with Iran and claimed Tehran has his proposal.

President Donald Trump made the comments during a visit to Qatar on the final stretch of his tour of the Middle East.

President Donald Trump described Tehran as the "most destructive force" in the region.

President Donald Trump turned to Iran and reiterated his stance against the nation if they don't come to a new deal with the U.S.

The fourth round of indirect U.S.-Iran nuclear talks are set to begin.

At least 65 people have died following an explosion at one of Iran's most important ports, according to officials.

Representatives from both sides in Oman called the meeting productive and are expected to sit down again for the fourth time, possibly as soon as next week.

The Port of Shahid Rajaee is a critical port in Iran.

A second round of talks completed earlier Saturday in Rome. Iranian officials described it as a step forward. Both sides are expected to meet again soon.

Iran and the United States are sitting down for a new round of talks on Iran's nuclear program as Vice President JD Vance visits Rome.

The Iranian Foreign Ministry announced that the second round on Tuesday.

The first round of talks were "well executed" in their "initial steps," Iran's Supreme Leader Ayatollah Ali Khamenei said in a post on his official X account on Tuesday.

U.S. envoy Steve Witkoff led the discussions, which were focused on Iran’s nuclear program.

Tehran last month rejected direct negotiations with the United States.

High-level delegations from the United States and Iran are meeting over the weekend in Oman to discuss Tehran's rapidly advancing nuclear program.

The first contact between the two nations since President Trump returned to office was described by the White House as positive.

An Iranian delegation arrived in Oman's capital, Muscat, on Saturday to meet with U.S. officials for "indirect talks" about Tehran's nuclear program, Iranian state-owned news agency IRIB reported.

Former U.S. Ambassador Ryan Crocker offered analysis of the planned nuclear talks between the United States and Iran this weekend.

Former Deputy Secretary of State Wendy Sherman says Iran should never be allowed to have a nuclear weapon and that the Trump administration must move quickly to prevent

Javed Ali, former National Security Council director for counterterrorism, says the fact that Iran and the US are meeting is a "big deal."

Ahead of expected talks between the U.S. and Iran, the State Department pushed back on the idea that the discussion would be a negotiation over Tehran's nuclear program.

Iranian officials confirmed Monday that Tehran would hold "indirect" high-level talks with U.S. representatives in Oman this weekend. ABC News’ Marcus Moore reports.

He made the surprise announcement sitting next to Israel's prime minister.

Sitting next to Israel's prime minister, President Trump said direct talks with Iran would start Saturday.

President Trump's sweeping new set of tariffs impact friends and foe alike, but also on the list are uninhabited islands while glaring omissions include Russia and Iran.

"In this response, although direct negotiations between the two parties are rejected, it has been stated that the path for indirect negotiations is open," Iran said.

ABC News’ Luis Martinez and contributor Mick Mulroy discuss the Trump administration’s airstrikes targeting the Yemeni group.

Over the weekend, President Donald Trump launched what he called "decisive and powerful military action" against Iranian-backed Houthi militants in Yemen.

"There are two ways Iran can be handled, militarily or you make a deal. I would prefer to make a deal," Trump told Fox host Maria Bartiromo.

The president said, “We have a situation with Iran that something is going to happen very soon.”

Stephen Troell was killed to avenge the death of Iranian general Qassem Soleimani in a drone strike, prosecutors said.

Emily Harding of the Center for Strategic and International Studies discusses what Syria’s shift in power means for the Middle East.

Singer Parastoo Ahmadi held an audienceless performance in one of Iran's traditional venues and posted it to YouTube.

Iran's Supreme Leader Ayatollah Ali Khamenei said in a speech Wednesday that the U.S. and Israel were behind the fall of former President Bashar Assad.

The FBI director nominee Kash Patel was hit with what is believed to be a cyberattack emanating from Iran, according to two sources familiar with the situation.

Prominent Iranian political activist, Kianoosh Sanjari, who took his own life on Wednesday in an act of protest, was buried Friday morning in Tehran.

Documents purporting to be Israel’s plans were leaked on the internet.

U.S. Central Command announced new strikes on Iran-linked militants in Syria on Tuesday in response to recent attacks on American personnel in the country.

Three people have been charged in connection with a conspiracy to assassinate President-elect Trump in a revenge plot for the deadly US drone strike, prosecutors say.

Three people have been charged in an alleged Iran-linked plot to assassinate President-elect Trump and several Iranian dissidents, according to a criminal complaint.

ABC News’ Aaron Katersky reports on the three people who, according to law enforcement sources, have been charged in an alleged plot to assassinate President-elect Donald Trump.

The woman stripped down to her underwear in an apparent act of protest after university security forces reportedly stopped her for not wearing a headscarf.

Israel has never conducted such a large-scale direct military attack on Iran. The IDF said it achieved its objectives but there are concerns this this will not deter future attacks from Iran.

Mick Mulroy, the former United States deputy assistant secretary of defense for the Middle East, discusses Israel’s overnight airstrikes on Iranian military targets.