Helene is now a Category 2 hurricane with 105 mph winds as it barrels toward the Florida Panhandle.

Category 3 -- which is considered a major hurricane -- begins when the storm’s winds reach 111 mph.

Helene is forecast make landfall Thursday night, between 10 p.m. and midnight, as a Category 3 hurricane with 120 winds.

Helene is "very large," so the storm's rain, wind and storm surge "will extend far away from the center and well outside the forecast cone, particularly on the east side," the National Hurricane Center warned.

"Comparing the system with previous hurricanes in the Gulf of Mexico over the past couple of decades, Helene is at the upper bound in terms of size," the NHC said.

-ABC News’ Max Golembo

North Florida residents who are in evacuation zones should leave now, Florida Gov. Ron DeSantis warned Thursday morning, since Hurricane Helene’s outer bands are quickly approaching the coast.

Florida’s Division of Emergency Management has partnered with Uber to provide free rides to shelters for Floridians under a state of emergency. Riders can use the code HeleneRelief, officials said.

At least 80 health care facilities -- including hospitals and nursing homes -- are evacuating, officials said.

One of the biggest hazards is falling trees, DeSantis said. He urged people to take cover if they hear trees cracking.

-ABC News’ Alex Faul

Hurricane Helene is forecast to bring six to 12 inches of rain, with isolated totals around 18 inches, to the Southeast.

The intense rainfall could cause "catastrophic and potentially life-threatening" flooding, the National Hurricane Center warned.

Helene is a large storm, so it could bring life-threatening storm surge for the entire west coast of the Florida Peninsula.

Storm surge could reach 15 to 20 feet in the Florida Panhandle. The Tampa area could get 4 to 8 feet of storm surge.

Click here to read how storm surge works and why it's so dangerous.