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Hurricane Helene live updates: 43 dead in Florida, Georgia, South Carolina, North Carolina
Flash flood emergencies are ongoing in multiple states.
Helene made landfall in Florida's Big Bend region Thursday night as a massive Category 4 hurricane -- the strongest hurricane to make landfall in the Big Bend on record.
Helene has since weakened and is now post-tropical, but its remnants will continue to produce dangerous weather. The center of the storm is now over Kentucky with heavy rain and gusty winds across a large area from Missouri to Ohio to the Carolinas.
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'Catastrophic' flooding in the forecast
Hurricane Helene is forecast to bring six to 12 inches of rain, with isolated totals around 18 inches, to the Southeast.
The intense rainfall could cause "catastrophic and potentially life-threatening" flooding, the National Hurricane Center warned.
What to know about storm surge
Helene is a large storm, so it could bring life-threatening storm surge for the entire west coast of the Florida Peninsula.
Storm surge could reach 15 to 20 feet in the Florida Panhandle. The Tampa area could get 4 to 8 feet of storm surge.
Click here to read how storm surge works and why it's so dangerous.
Helene strengthens to Category 2
Helene has strengthened to a Category 2 hurricane with winds of 100 mph.
The storm will continue to strengthen throughout the day and is forecast to be a major hurricane by the time it makes landfall Thursday night.
Damaging winds expected as Helene's speed increases
Hurricane Helene's landfall may see "damaging winds" penetrate as far inland as major metro areas like Atlanta, Georgia, the National Hurricane Center warned.
The storm is "strengthening and expected to bring catastrophic winds and storm surge to the northeastern Gulf Coast," the NHC said in its latest update.
A hurricane warning is currently in place for parts of Florida and Georgia. This includes Tallahassee and Apalachicola, Florida, and Valdosta, Columbus and Macon, Georgia.
A tropical storm warning is in place for cities including Miami, Orlando, Jacksonville and Atlanta. Dothan, Alabama, Charleston, South Carolina, and Asheville, North Carolina are also under tropical storm warnings.
The hurricane is expected to gather speed to Category 3 status -- with winds of 111 mph and above -- by the time it makes landfall on the Florida coast on Thursday night.
Helene's damaging winds could reach Atlanta and other cities by Friday morning, subsequently passing into the Appalachians and Ohio Valley by Friday afternoon.
-ABC News' Max Golembo