Wildfires threaten several thousand homes in Southern California
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WATCH: Flames shut down busy Interstate 405 and threatened the Getty Center, which holds priceless artworks.

Firefighters in Southern California began battling a new wildfire Wednesday that engulfed an area of Los Angeles near the Getty Center and the Skirball Cultural Center.

The brush fire ignited around 5 a.m. CT near 405 Freeway and Mulholland Drive in the Brentwood neighborhood of Los Angeles. More than 350 firefighters were on the scene with helicopters hovering above as the so-called Skirball fire was 5 percent contained as of Wednesday night.

Authorities have shut down northbound 405 for an "undetermined period" as a result of the blaze and ordered mandatory evacuations for parts of the affluent Bel-Air neighborhood, according to the Los Angeles Fire Department.

The smoke can even be seen from space -- the International Space Station shared photos of the fires on Twitter Wednesday.

Flames burn near power lines in Sycamore Canyon near West Mountain Drive in Montecito, Calif., Dec. 16, 2017. Photo Credit: Mike Eliason/Santa Barbara County Fire Department via AP
This undated photo obtained from the Santa Barbara County Fire, shows flames from the Thomas Fire near homes. Photo Credit: Handout/AFP/Getty Images
Cal Fire captain Jason Novak observes fire behavior during a firing operation at the Thomas Fire above Los Padres National Forest, Calif., Dec. 13, 2017. Novak is part of the Cal Fire Lake Napa Unit.

Photo Credit: Stuart Palley for ABC News

A Cal Fire firefighter observes fire behavior during a firing operation in the Los Padres National Forest, Calif., Dec. 13, 2017.

Photo Credit: Stuart Palley for ABC News

Wildfire flames burn on a hillside from the Thomas Fire near Montecito, Calif., Dec. 12, 2017.



More than 6,000 fire personnel are still battling the Thomas fire, which has singed more th... Photo Credit: Patrick T. Fallon/Reuters

A vehicle burns after the Thomas Fire surged through Toro Canyon, Calif. on Dec. 11, 2017. By midnight the fire had burned over 230,000 acres, was 20% contained, destroyed 880 homes, and was the 5th largest fir... Photo Credit: Stuart Palley for ABC News
Firefighters battle flames on State Route 150 between Carpinteria and Ojai Calif., Dec. 11, 2017.

Photo Credit: Tom Tingle/The Arizona Republic/USA Today

Christmas decorations illuminate a house as the growing Thomas Fire advances toward Santa Barbara County seaside communities, Dec. 10, 2017, in Carpinteria, Calif.

Photo Credit: David McNew/Getty Images

Firefighting helicopters try to save a house from the Thomas wildfire in Carpinteria, Calif. on Dec. 10, 2017.

Photo Credit: Mark Ralston/AFP/Getty Images

Fire fighters attack the Thomas Fire's north flank with backfires as they continue to fight a massive wildfire north of Los Angeles, near Ojai, Calif., Dec. 9, 2017. Photo Credit: Gene Blevins/Reuters
Patricia Hampton wipes away tears on her cot at the county fairgrounds in Ventura, Calif., Dec. 7, 2017. Wildfires menacing the greater Los Angeles area have forced thousands of evacuations; Hampton lost her ho... Photo Credit: Hilary Swift/The New York Times/Redux
Firefighters work to extinguish the Thomas Fire as it burns past the 101 Highway towards the Pacific Coast Highway in Ventura, Calif., Dec. 7, 2017. Photo Credit: Kyle Grillot/AFP/Getty Images
The Thomas Fire reaches the Northbound 101 freeway north of Ventura, Calif. As of late Dec. 6, the Thomas fire had grown to 96,000 acres and was 5 percent contained as the blaze continued to rage and caused mor... Photo Credit: (Wally Skalij/Los Angeles Times/Polaris
Jeff Lipscomb embraces his daughter Rachel, 11, as they stand over where her room was and see her burned collection of books after their home was destroyed in a fire in Ventura, Calif., Dec. 6, 2017. Photo Credit: Marcus Yam/Los Angeles Times via Polaris
Flames consume a home as a wildfire burns in Ojai, Calif., on Dec. 7, 2017. Photo Credit: Noah Berger/AP
Firefighters monitor a section of the Thomas Fire along the 101 freeway on Dec. 7, 2017 north of Ventura, Calif. The firefighters occasionally used a flare device to burn-off brush close to the roadside. Strong... Photo Credit: Mario Tama/Getty Images
NASA astronaut Randy Bresnik shared images of the Southern California wildfires taken from the International Space Station on Dec. 6, 2017. Photo Credit: @AstroKomrade/Twitter
Paul and Erica Mattesich embrace before sifting through rubble at their Ventura, Calif., home on Dec. 6, 2017. The family lost their house when the Thomas fire tore through their neighborhood on Colina Vista. Photo Credit: Noah Berger/AP
A painting rescued by firefighters sits on the ground as they work to extinguish fires in a home during the Skirball Fire which began early morning in Bel-Air, Calif. Dec. 6, 2017. Photo Credit: John Centrino/EPA
A firefighter walks out of a vineyard owned by Rupert Murdoch that was damaged by the Skirball fire near the Bel Air neighborhood on the west side of Los Angeles, Dec. 6, 2017. Photo Credit: Andrew Cullen/Reuters
Burnt cars lie among the ruins of the Hawaiian Village apartment complex that was destroyed by the Thomas Fire in Ventura, Calif., Dec. 6, 2017. Photo Credit: Mike Nelson/EPA
Gordon Fischer rests in an evacuation center set up at the Ventura County Fairgrounds after he was displaced by the Thomas Fire in Ventura, Calif., Dec. 6, 2017. Photo Credit: Mike Nelson/EPA
Firefighters remove furniture from a home destroyed in a wildfire in the Bel Air district of Los Angeles, Dec. 6, 2017. Photo Credit: Jae Hong/AP
A firefighter works to save burning houses as ash falls along Linda Flora Drive during the Skirball Fire in Los Angeles, Dec. 6, 2017.

The "Skirball" fire ignited before 5 a.m. (1300 GMT) and quickly... Photo Credit: AFP/Getty Images

Los Angeles firefighters battle to contain flames to a burning home and prevent the fire's spread to adjoining properties in the Bel Air district of Los Angeles on Dec. 6, 2017. Photo Credit: Reed Saxon/AP
Vehicles pass beside a wall of flames on the 101 highway as it reaches the coast during the Thomas wildfire near Ventura, Calif., Dec. 6, 2017.

Photo Credit: Mark Ralston/AFP/Getty Images

Heavy smoke covers the seaside enclave of Mondos Beach beside the 101 highway as flames reach the coast during the Thomas wildfire near Ventura, Calif., on Dec. 6, 2017. Photo Credit: Mark Ralston/AFP/Getty Images
Brushfire near the 405 Freeway in the Bel-Air neighborhood of Los Angeles, Dec. 6, 2017. Photo Credit: JoeBrennan87/Twitter
A Los Angeles County firefighter prepares to battle a hot spot on the "Creek Fire" in the Lake View Terrace area of Los Angeles, Dec. 5, 2017. Photo Credit: Chris Carlson/AP
Firefighters work to put out a blaze burning homes early on Dec. 5, 2017, in Ventura, Calif. Authorities said the blaze broke out Monday and grew wildly in the hours that followed, consuming vegetation that has... Photo Credit: Ryan Cullom/Ventura County Fire Department via AP
Horse owners start to evacuate their horses as the Creek Fire intensifies on Foothill Blvd in Lake View Terrace, Calif., Dec. 5, 2017. Photo Credit: Joe Lumaya/The Star via USA Today
A man watches as a wildfire burns in Ventura, Calif., on Dec. 5, 2017. Photo Credit: Noah Berger/AP
A man uses a hose to extinguish the Creek Fire as it burns along a hillside near homes and horses in the Shadow Hills neighborhood of Los Angeles on Dec. 5, 2017. Photo Credit: Kyle Grillot/AFP/Getty Images
The Thomas Fire burns along a hillside near Santa Paula, Calif., on Dec. 5, 2017.

More than a thousand firefighters were struggling to contain a wind-whipped brush fire in southern California on December 5 t... Photo Credit: Kyle Grillot/AFP/Getty Images

Homes burned to the ground by the Thomas fire are viewed from a helicopter in Ventura County, Dec. 5, 2017, Ventura, Calif. Photo Credit: Brian van der Brug/Los Angeles Times/Polaris
A wildfire threatens homes as it burns along the 101 Freeway Tuesday, Dec. 5, 2017, in Ventura, Calif. Photo Credit: AP
Smoke rises behind a leveled apartment complex as a wildfire burns in Ventura, Calif., Dec. 5, 2017. Photo Credit: Noah Berger/AP
A photo released by the Ventura County Fire Department shows the Thomas Fire, which forced more than 25,000 people to evacuate Ventura, Calif., Dec. 4, 2017. Photo Credit: Ventura County Fire Department/EPA

Los Angeles Mayor Eric Garcetti said the Skirball fire has damaged 11 structures and destroyed at least six structures in the area, all residences, so far. Garcetti has declared a local state of emergency in response to the Skirball fire, which had burned at least 150 acres in Bel Air by Wednesday afternoon, his office said in a press release.

The Los Angeles Unified School District is closing all 265 schools in the San Fernando Valley and the west side of Los Angeles through Friday due to the Skirball fire, the school district said in a press release.

A major Santa Ana weather event with wind gusts between 70 and 80 mph, along with low relative humidity, is to blame for the fire emergency near Los Angeles.

While about 4,600 people have been affected by the fire, some evacuation orders might be lifted Wednesday evening depending on the progress, officials said. Conditions are favorable, but the Santa Ana winds will return this evening, so firefighters are working on making progress before the winds pick back up, officials said.

All residents, especially those in mountainous areas, should be ready to go at a moment's notice, officials said.

Meanwhile, fire crews are still fighting a fast-moving wildfire in Ventura County that officials said on Wednesday night has charred at least 90,000 acres of land -- up from 65,000 acres a day earlier.

Thousands of people have been forced to flee their homes since the flames ignited. The so-called Thomas fire began as a 50-acre brush fire in foothills east of Santa Paula on Monday and it rapidly grew to 10,000 acres in just four hours, authorities said.

Emergency officials originally said a person died in the fire, but later clarified that a dog was killed.

Smoke rises behind a leveled apartment complex as a wildfire burns in Ventura, Calif., Dec. 5, 2017.

More than 50,000 people from 15,000 homes have been evacuated, officials said Wednesday night, up from 38,000 people on Tuesday. Officials have gone door-to-door to enforce mandatory evacuations.

So far, about 2,500 homes were under mandatory evacuation in Ventura County as the flames moved southwest toward the coast. Officials said several thousand homes in nearby areas were also evacuated because of the Thomas fire, though they cautioned that was a rough estimate.

"We urge you, you must abide by these evacuation notices," Ventura County Sheriff Jeff Dean said at a press conference late Monday. "We saw the disasters and the losses that happened up north in Sonoma, and this is a fast, very dangerous moving fire."

Smoke rises from the 'Thomas Fire' as it spreads over thousands of acres near Santa Paula, Calif., Dec. 4, 2017.

More than 150 structures, including a 60-unit apartment complex, have been destroyed by the Thomas fire and over 12,000 structures are threatened, according to the California Department of Forestry and Fire Protection.

The massive fire has also knocked out power for more than 190,000 customers in Ventura and Santa Barbara counties, according to Southern California Edison.

A home burns as strong winds push the Thomas Fire across thousands of acres near Santa Paula, Calif., Dec. 5, 2017.

Intensified by strong winds and harsh weather conditions, the Thomas fire is pushing west toward the Pacific Ocean. At 0 percent containment, officials said critical fire conditions are expected throughout the week.

California Gov. Jerry Brown has declared a state of emergency in Ventura and Los Angeles counties.

At a press conference Tuesday, Los Angeles County Deputy Fire Chief David Richardson described the unpredictable conditions that firefighters are facing as they attempt to contain the blaze.

"You can only imagine the impact this weather is having on the fire front," Richardson said. "We're chasing the fire and trying to get ahead of it. And we're chasing multiple fronts."

Firefighters in Ventura County said they were dealing with winds of 30-50 mph -- slightly up from 25 to 50 mph a day earlier -- which they said made it impossible to fight the fire via aircraft.

"The prospects for containment really are not good. Mother Nature is going to decide when we have the ability to put it out, because it is pushing hard with the wind," Ventura County Fire Chief Mark Lorenzen said at a press conference Monday night.

"As far as getting ahead of the fire, that's exactly what we're doing right now, but it's in defense of structure and property right now, not actually trying to put the fire out," he added.

Firefighters are also battling a growing brush fire in the Kagel Canyon area above the Sylmar neighborhood in Los Angeles that has scorched over 11,000 acres since Tuesday morning.

Hundreds of firefighters and a number of water-dropping helicopters were on scene as the so-called Creek fire remained at 0 percent contained. The Los Angeles Fire Department said homes in the affected area have been damaged, without providing an exact number.

At least seven firefighters were injured while fighting these flames. The extent of their injuries was unknown but are believed to be not life-threatening, officials said.

More than 150,000 people were affected by evacuations related to the Creek fire, officials said.

Another wildfire that began in Santa Clarita on Tuesday morning has burned 7,000 acres, spreading across the Los Angeles County line into Ventura County.

At 5 percent contained, the so-called Rye fire has not damaged any homes but has prompted school closures and the evacuation of 1,300 people, according to the Los Angeles County Fire Department.

Overall, more than 4,000 firefighters are battling these four wildfires in Southern California. Authorities say strong offshore winds and dry conditions are hampering efforts to contain these blazes, which have collectively scorched over 83,000 acres.

ABC News' Matthew Fuhrman and Michael Kreisel contributed to this report.