Scientists Find Gene for Emotional Memory

Some May Be Genetically Predisposed to Retain Intense Memories

ABC News Medical Unit

July 30, 2007 —

The Kennedy assassination. The Challenger explosion. The Sept. 11 attacks on the World Trade Center.

Nearly anyone who was alive at the time of these tragedies would be able to provide a vivid recollection of the event. As for more commonplace emotional memories — a wedding, the loss of a loved one — some people seem more inclined toward this type of recall than others.

Now, according to new research, there's a genetic reason why some have the gift or curse of retaining emotional memories.

The research, published Sunday in the journal Nature Neuroscience, found that those with a certain common genetic variation tend to more readily remember emotionally charged events, for better or for worse.

There are specific chemicals in the brain that have the effect of covering up old emotional memories — like a photo that fades with time. But for those with this particular genetic variation, these "images" are preserved, resulting in enhanced emotional memory.

About a third of Caucasians and 12 percent of African-Americans possess the variant.

"This mechanism plays an important role in remembering dangerous situations, as well as happy ones," said lead study author Dr. Dominique de Quervain, a researcher in the psychiatric division at the University of Zurich.

"For example, remembering where along a street an accident happened is important, so it doesn't happen again."

The researchers showed 435 young Swiss adults 30 pictures — 10 that were neutral, 10 that had a positive emotional connotation and 10 with a negative emotional meaning. The team asked the subjects to rate their reaction to each photograph and, after 10 minutes, to describe each picture in a few written words.

The participants who carried the gene variant had a much better recall of both the negative and positive pictures, but there was no difference between the groups when it came to remembering the neutral pictures.

"So what we found was that this genetic variant related to enhanced emotional memory had nothing to do with normal memory," said de Quervain.

To understand the gene variant in other populations, the researchers tested Rwandan civil war refugees and found similar results; those who carried the gene variant had an easier time recalling both the positive and the negative pictures.

One Thing to Remember: You Can't Have It All!

Brain researchers said that there is a reason why humans have evolved such a mechanism to remember certain events, but not others.

"We can't remember everything," said Dr. Jeff Victoroff, associate professor of clinical neurology and psychiatry at the University of Southern California Keck School of Medicine.

"As the human brain evolved, we needed a good system that would ensure that we remember those things that are truly important for survival and reproduction," he said. "Virtually everything else is optional."

Victoroff agreed with the study's authors that emotional memory in particular serves two purposes: "The immediate benefit of getting us revved up for fight or flight, and the long-term benefit of helping us remember dangerous circumstances so that we can judge whether the gains of putting ourselves through the same situation again are likely to be worth the risk."

Humans who were adept at utilizing these tricks were the ones who survived and became our ancestors.

Those who had brains that didn't separate the really important memories from the forgettable ones were more likely to die off, according to Victoroff.

Treating Trauma

While the research may one day help scientists and psychologists develop better ways of treating anxiety or post-traumatic stress disorder, some experts warn that one gene doesn't hold all the answers.

"It is not clear that information about the ability to recall positive or negative memories is relevant to the treatment of PTSD," said Rachel Yehuda, director of traumatic stress studies at Mount Sinai School of Medicine in New York.

"It is not the case that people who remember things better or worse are at greater or lower risk for PTSD," she said. "The idea of PTSD treatment is to allow the person the opportunity to process a memory so that it no longer has the power to cause physiological arousal and distress."

Victoroff agreed with Yehuda's assessment. "Those of us who have tried to understand PTSD have increasingly realized that this is probably not a single unified psychiatric disorder but a grab bag of symptoms thrown together by a committee," he said. "The symptom of re-experiencing is associated with a genetic variation, while the other symptoms of so-called PTSD had no relation to the gene."

Therefore the new knowledge of re-experience outlined in the study could help in the treating of one symptom of PTSD.

Said Victoroff: "The discovery that storing emotional memories is linked to a particular neurotransmitter operation paves the way to specific treatments that will hopefully save people from the terrible pain of re-experiencing the worst thing that's ever happened to them."