But there are some happy endings, because some of these pets will be adopted by new owners.
"I'm hopeful that … she'll get someone who will love her as much if not more than me," Wise said. "Sometimes you have to do what's best for them, and I think this is best for her."
But that doesn't ease today's pain.
"It hurts," Wise said. "And I know one thing. I won't get another animal … 'cause separation is too hard."
Thinking about adopting a pet? CLICK HERE for tips from the Humane Society.