"She's my baby," Wise said. "I have two grown children and she's what I call my most obedient child. I've tried and I've tried so hard. And I've had to accept the reality that if you don't have your home, there's nowhere to really put your dog."
But there are some happy endings, because some of these pets will be adopted by new owners.
"I'm hopeful that … she'll get someone who will love her as much if not more than me," Wise said. "Sometimes you have to do what's best for them, and I think this is best for her."
But that doesn't ease today's pain.
"It hurts," Wise said. "And I know one thing. I won't get another animal … 'cause separation is too hard."
Thinking about adopting a pet? CLICK HERE for tips from the Humane Society.