Their applicants come from "all over the map, young and old," according to Calhoun. One was a 71-year-old with a doctorate from Harvard University.
Calhoun found the alternative newspaper in 1977, "back when people were thinking something else, when they were singing 'Rocky Mountain High,'" she told ABCNews.com.
Until now, a news reporter has been covering the industry under the pseudonym Mae Coleman, after a character in the 1936 drug-scare film "Reefer Madness."
But according to Calhoun, "He doesn't even like pot."
The latest hire will write the new column, "Mile Highs and Lows."
"You want to see a great writer with opinions and who is entertaining," she said. "Pot dispensaries are like restaurants, and you are talking about atmosphere, history or owners, not just the pot."
"Some are like head shops, some are like spas and some are like coffee shops and some are just down and dirty and skanky," said Calhoun. "That's what the reviewers will tell us."
But for those who are more technically minded and who may have lost jobs on Wall Street, look no further.
Full Spectrum Laboratories founder Bob Winnicki -- a former medical student and researcher -- is looking for a few good men (and women) to be marijuana testers.
The 35-year-old "gangaprenuer" aims to introduce quality control to the burgeoning cannabis industry, which is thriving in 14 states nationwide.
His start-up company tests samples of medical-marijuana products and quantifies their potency, helping doctors and patients determine correct dosages of the drug.
Winnicki dropped out of his third year of medical school at the University of Colorado after being approached by his "stoner" friends.
"'Hey, man, could you like come up with a way to test cannabinoids in plants?'" Winnicki says they asked him.
"I hit the literature," said Winnicki, who had previously run two technology companies. "I missed doing research and thought, yeah, that could be done. But we had to do it right -- not with Home Depot level equipment."
"It was the easiest money I ever raised," he said. "A lot of wealthy people in the industry see value in it."
When Winnicki was studying to be a doctor, people at parties thought he was "pretty cool," but now that he runs a marijuana company, "I am one of the most interesting people in the room."
He is banking on marijuana being legalized outright in the next five years and predicts he can "handle the whole industry."
Today he is looking for scientists and a sales team, but if business booms, there will be more openings.
His first hire was Betty Aldworth, a 33-year-old director of outreach and development.
Alternately known as Queen Betty and Queen of Awesomeness, she always gets a reaction when she tells people about her line of work.
"It's hysterically funny," she told ABCNews.com. "A lot of my friends are users or know someone who can benefit from medical marijuana. There's a lot of, 'Whoa, really?' Folks are completely blown away."
Still, Aldworth sees her job as a medical pioneer. Her father has been disabled with a lifelong spinal condition and her grandmother suffers from osteoporosis.
"He's in extraordinary pain and on a lot of narcotics that are causing side effects, making him even more ill," she said. "My grandmother is 80 and she's not going to pick up a joint."