"Lost" co-creator and executive producer Damon Lindelof said the coincidence might be good karma for the show's dedicated fans.
"Considering the show pretty much drove its fans crazy for six years, it seems only karmically just that it has finally decided to give back," Lindelof told ABC News exclusively.
Fellow executive producer Carlton Cuse said via tweet not to blame the show's creators if the Lotto connection, like many of "Lost's" plot twists and turns, remains unsolved.
"I'm sure there is a larger, mystical reason this happened, but in this case if it never gets explained, don't blame me or Damon," executive producer Carlton Cuse said via tweet.
The numbers Reyes used to win $156 million were: 4, 8, 15, 16, 23 and 42, four out of the six numbers picked on Tuesday.
The numbers played a pivotal role throughout the series; from Reyes' personal tragedies, sucha as the death of his grandfather, to the appearances on the island during crucial turning points in the storyline.
As players check their tickets this morning, if you'd won Tuesday's jackpot, what do you do?
First of all, you would never see the full $380 million. Off the top, the lottery withholds 25 percent for federal taxes, and then another 6 or 7 percent for those who have state taxes, which vary by location. And you still could owe many millions more.
Lee McDaniels won $5 million in September. On Tuesday, he was relaxing on a golf course outside Atlanta.
"After taxes and everything," he said, "I got about $2.8 million."
His advice for the big $380 million winner? Take some time to get your affairs together, study up and get a financial adviser.
"I would just take about a month before I would do anything," he said.
Margaret DeFrancisco of the Georgia Lottery Corp. had more advice.
"Change your phone number and learn how to say 'no,'" she said.
Then, there's always the question of whether you should take the annuity or the much lower one-time payment.
Financial analyst Ray Lucia said that, for purposes of this daydream and this huge jackpot, "I'm going to take the annuity payment of about $9 million a year, net of tax."
For the $380 million jackpot, the annuity would pay $13.6 million each year for the next 26 years, so you won't be able to spend all of your winnings at once.
The largest Mega Millions jackpot ever won was $390 million in March 2007, according to the Mega Millions website.
Elaine and Harold Messner of Woodbine, N.J., and Eddie Nabors of Dalton, Ga., bought the winning tickets ($195 million each).
What to do with that check? How about move into Aaron Spelling's former 123-room Beverly Hills mansion?
Buy the Minnesota Twins with money to spare?
Or if you're a saver, put it all in a 5-year CD.
According to BankRate.com, you can lock in 2.27 percent in interest today. That'll pay you more than $3.6 million each year.
ABC News' Michael S. James, Kevin Dolak, John Griffin, Jennifer Metz and The Associated Press contributed to this story.