Elvis Presley, the "King of Rock 'n' Roll," died Aug. 16, 1977, in Memphis, Tenn., at age 42. Presley's body was discovered by his road manager, Jerry Esposito, in a bathroom in the singer's multimillion-dollar Graceland Mansion. An autopsy indicated Presley died of cardiac arrhythmia. The singer, who seamlessly blended the elements of blues, rock and even gospel into his music, is one of the most influential musicians in American history. Similar to Jackson, Presley became a recluse, in the 1960s, in the aftermath of fame and financial troubles. According to the Los Angeles Times, Presley had 14 drugs in his system when he died, including the painkillers morphine and Demerol; Chloropheniramine, an antihistamine; tranquilizers Placidyl and Valium; the opiate codeine, the prescription sleeping pill Ethinamate, Quaaludes and one other unidentified depressant. In 1979, Presley's private physician, Dr. George Nichopoulos, was charged with "indiscriminately prescribing 5,300 pills and vials for Elvis in the seven months before his death," according to Rolling Stone. He was later acquitted.
Anna Nicole Smith was a well-known sex symbol whose life tragically ended at age 39. On Feb. 8, 2007, the Playboy playmate was found unresponsive in a room at the Hard Rock Hotel & Casino near Hollywood, Fla. She was taken to a hospital but was pronounced dead shortly after. Law enforcement cited the cause of death as a prescription drug overdose. A toxicology report also found human growth hormone and chloral hydrate, a sleep medication. Medical examiner Joshua Perper said he did not believe Smith tried to kill herself. Smith's boyfriend, Howard K. Stern, and two doctors were charged in March 2009 with giving Smith thousands of prescription drugs between June 2004 and January 2007.
Smith fought bouts of depression throughout her life, including after the death of her son Daniel. While presenting at the 2004 American Music Awards, Smith appeared heavily sedated, often slurring her words. Smith told "Entertainment Tonight" that her addiction to prescription drugs began during the legal battle over the estate of her husband, J. Howard Marshall. But her withdrawal led to severe panic attacks and even seizures. "You just, like, leave your body," Smith said. "It's, like, unexplainable. It's like -- like one time I went to the park, my friend took me to the park, and I thought I was walking on stilts."