Stamos, like Alexander, has joked about the prospect. "Contrary to the rumors, i am not replacing charlie sheen on two and half men," he tweeted Feb. 25. "however, martin sheen has asked me to be his son." (Like Lowe's publicist, Stamos' representative refused to talk about the replacement reports.)
Woody Harrelson. Relation to Charlie Harper: pot dealer. Why him? Harrelson champions marijuana and has proven adept at playing a TV buffoon (see: "Cheers," "Will and Grace").While "Two and a Half Men" has never shown Harper explicitly using drugs, between his stints boozing on the beach, gambling and picking up women, it's reasonable to suspect that he at least bumped into a ganja-selling ne'er do well.
Matt LeBlanc. Relation to Charlie Harper: cousin. Why him? "Friends'" loveable Joey Tribiani needs a new hit show (which was the premise of "Episodes," the LeBlanc Showtime comedy that just wrapped its first season). His characters chronically love women. It follows that he could be from the more jovial side of Harper's gene pool.
Luke Perry. Relation to Charlie Harper: fellow Julliard classmate (Harper attended the prestigious music school but got kicked out). Why him? Perry played a brooding bad boy on "Beverly Hills, 90210." With a perpetual smirk on his face, he could pass for Harper's college crony.
Jeremy Piven. Relation to Charlie Harper: wingman. Why him? "Entourage" is ending. Piven needs a new home. On screen and in life, he's audacious enough to be the type of guy with whom Harper would want to go babe-hunting.
David Hasselhoff. Relation to Charlie Harper: uncle. Why him? Hasselhoff and Sheen have a lot in common, i.e., drunken benders caught on tape. It wouldn't be a shock if Hasselhoff were his uncle in real life.
Gary Busey. Relation to Charlie Harper: uncle. Why him? Like Hasselhoff, the reasons for this casting are grounded in reality. Busey's one of the few men in Hollywood whose quotes rival the nonsensical bombast of Sheen's.
Emilio Estevez. Relation to Charlie Harper: long lost half-brother. Why him? His last hit was "D3: The Mighty Ducks" in 1996. He guest-starred on an episode of "Two and a Half Men" in 2008. And, most significantly, he is Sheen's actual brother.