"Desperate Housewives" star Marcia Cross, who had twin girls at 44, told People magazine she did in vitro a week after she married husband stockbroker Tom Mahoney in 2006.
"I had already been through infertility treatments," the actress told Health magazine. "It's very, very difficult to get pregnant in your 40s. It's costly and tough on your body and your relationship."
Celine Dion also went public with her struggles to have a child with much older husband and manager Rene Angelil. After years of publicly wishing for a child, the Canadian-born singer underwent IVF treatments in New York and gave birth to son Rene-Charles in 2001, when she was 32.
In 2005, Dion openly discussed keeping another usable embryo on ice to have as a future sibling for Rene-Charles.
"I'm approaching 40 years old, and I have to tend to that," she told a French magazine. "This frozen embryo that is in New York is my child waiting to be brought to life."
Whether that's the embryo now growing inside her, Dion, now 41, is currently expecting her second child, also conceived with the help of the same Manhattan infertility specialist.
Actress Garcelle Beauvais-Nilon has been forthright about the problems she faced getting pregnant. It took five years, three miscarriages and two rounds of in vitro fertilization to conceive twin sons Jax and Jaid in October 2007.
"It's hard in every single way: emotionally, physically," she told People.
Jane Seymour also recounted for WebMD her struggles conceiving twin boys at age 44.
"I had had in vitro fertilization, and I was scanned and watched from day one," she said.
Some celebrities are even willing to push the envelope past 50, like in the case of former GMA co-host Joan Lunden and model Cheryl Tiegs. Lunden who had two sets of twins through a surrogate after turning 50, has never discussed whether she used an egg donor.
But Tiegs, who was 52 at the time, said she used her own eggs.
"When we were trying to get pregnant, I produced one perfect egg, and then when we did the one with the surrogate, I had three eggs. So I don't see why that's such an impossibility, when my system is in -- still in good working order," Tiegs told Larry King. "It's not easy. I had to have a lot of shots. But I don't see why -- it certainly is possible."
Many questioned Tiegs' claim.
"A twin pregnancy using 50-year-old eggs is a medically unprecedented event," Paulson said. "It's not impossible, but very improbable."
But like Mendel, Paulson said he believes it's up to the parents to decide how they tell the story of their child's birth.
"I want to respect people's privacy," Paulson added. "Even if it's not medically impossible, why not grant them the element of doubt they wish to have. Do we want to have that kind of thing revealed to the children before they have had a chance to hear about it from their mother?"