He has had limited success as a director. His 2007 film "Run, Fat Boy, Run," a British romantic comedy, bombed at the box office, but USA Today said Schwimmer possessed filmmaking finesse "having wisely chosen strong comic material for his debut behind the camera." He also reportedly met his soon to be wife during the making of the film.
In front of the camera, Schwimmer, 43, hasn't seen much action besides guest starring roles on "30 Rock" and "Entourage," where he played himself. Ironically, in the "Entourage" episode, agent Ari Gold tries to steer his career back to television.
But, according to the Daily Mail, Schwimmer has had to return to auditioning for parts, even while being turned down for top roles.
Perry, 40, has been unable to find his groove since playing Chandler on the hit sitcom.
His attempts to repeat his "Friends" success on the small screen have fallen flat. His 2006 series "Studio 60 on the Sunset Strip" was dropped by NBC after the first season because of poor ratings. Last year, he tried again to return to television as a radio talk show host in "The End of Steve," but the dark comedy was scrapped after just one episode.
Perry has had equally bad luck on the big screen. In his first film role after "Friends," Perry played a man a chronically depressed man in the 2007 movie "Numb." The film flopped at the box office. His most recent role in "17 Again" was better received, but he played second banana to star Zac Efron.
In the past, Perry has admitted to struggles with depression and alcohol and prescription drug addiction. Production on 2002's "Serving Sara" had to be shut down for three months while Perry checked into rehab.
"Your consciousness has to change and, I was very lucky and smart enough to realize that at that moment, it was life and death time, and movies, acting, dating, sports and everything just have to take a sideline to this," he told Film Monthly at the time.
Cox, 45, turned her focus to family following the end of "Friends."
After trying for so long to conceive, she was finally pregnant with daughter Coco when "Desperate Housewives" creator Marc Cherry wanted to cast her as Susan. The role went instead to Teri Hatcher.
A few years later, in 2007, she launched her comeback playing a tabloid editor in the FX sitcom "Dirt," which she and husband David Arquette produced. The show was canceled after the second season because of poor ratings. A long guest appearance on the NBC series "Scrubs" led to Cox's current role as a 40-something divorced real estate agent re-entering the dating scene in ABC's "Cougar Town."
"I think Courteney Cox is great at playing the comedy of discomfort," executive producer Bill Lawrence told ABCNews.com.
Lawrence, who also produced "Scrubs," approached Cox with the sitcom after he heard through the grapevine that she was looking to do comedy again. "She's a fearless comedian."