Are Justin Timberlake and Jessica Biel Really Over?

Oct. 22, 2009— -- Girlfriends come and go for Justin Timberlake, but there seems to be some question whether his latest, Jessica Biel, is really gone.

Amid rumors that Timberlake and Biel have split, his grandmother, Sadie Bomar, told a British magazine that despite his two-and-a-half-year relationship with the actress, the only thing JT is really committed to is his career.

"Jessica was keen to marry, but Justin isn't ready," Bomar told Closer earlier this month. "He's busy writing new material and he works hard to be successful -- he's really focused on that. As far as we're concerned, he's always been single.

"The girlfriends come and go, but we believe nothing has ever been serious," the grandmother added. "Justin does his own thing and he isn't ready to marry just yet."

Perhaps that explains why Timberlake has dated some of Hollywood's most beautiful women, including Britney Spears and Cameron Diaz -- and broke up with both of them.

It's unclear, though, whether he and Biel are finished just yet. Reps for Timberlake and Biel did not return requests for comment.

But E! gossip columnist Ted Casablanca said he believes the writing is on the wall.

"What I hear more from people who know them is that it's ending, that it's not going to work," he told ABCNews.com

It's a good thing too, Casablanca said.