But there's a notable group of celebrities who are childless, either by circumstance or choice, and many of them have begun to speak out.
"I feel like a loser," she said. "I would definitely love to be a parent. But I definitely don't think I want to do it on my own."
Walsh split from her film executive husband Alex Young in 2008 after only 14 months of marriage and a seven-month courtship. Their bitter divorce, splashed in the tabloids, was finalized more than a year later. The settlement included flipping a coin over disputed furniture and artwork.
"Oh my God. The worst thing ever. It was so public, and yet it was so legal-embroiled. You couldn't talk about anything," Walsh told More.
A year later, the actress is coming to terms with her failed marriage and her child-free lifestyle.
"Things are just going to go the way they go," she said. "I thought I'd be married and have three or four kids. I always knew I wanted to be an actress, but I think I always wanted a quote-unquote normal life because I had a very untraditional upbringing."
Walsh's life may not be the norm but she's certainly not alone. Here are four other child-free stars:
While Oprah Winfrey has long celebrated mothers as having the most difficult and important job on the planet, she finally decided that being a mom wasn't for her.
Last year, the 57-year-old talk mogul told ABC News' Barbara Walters that she and fiance Stedman Graham have no plans to marry and start a family, though they once considered adoption.
"For a while I thought, 'Well, maybe,' every time I went to Africa, and Stedman says this too. Every time I went to Africa he didn't know when I got off the plane if I was going to have one or two or ten children," Winfrey told Walters.
Instead of a family, the driven Winfrey built a business empire, including her recently launched network OWN. Dubbed the most powerful celebrity in the world, with an estimated wealth of $2.7 billion by Forbes Magazine, Winfrey admits she could not have managed being a successful career woman and mom.
"I could not... have had this life and lived it with the level of intensity that is required to do this show the way it's done," Winfrey said. "I'd be one of those people that the kid's coming and saying, 'Mom, you've neglected me.'... So I have no regrets about that. I have none ... not one regret about not having children because I believe that ... it is the way it's supposed to be."
"Sex and the City" star Kim Cattrall, 54, also reconsidered her desire to have children.
In 2003, she told Winfrey's magazine O, The Oprah Magazine, that she had always assumed she would be a mother like her own mother.
"When I was 5, my fantasy was to have a hundred dogs and a hundred kids," she said.
But when she found herself single in her late 30s and exploring options for having a child on her own, she decided being a mom wasn't her destiny.