"I feel like honestly that God sent me those lyrics and that melody," Gaga told the music magazine NME. "When you feel a message to give to the world and people are shooting arrows through it ... there's no way for something that pure to be wrong."
Gaga's latest controversy is ground well tread by her idol Madonna, who has long been a lightning rod for Christians, starting with her early hit, "Like a Virgin."
But it was Madonna's "Like a Prayer" video, with its symbolic Catholic images such as burning crosses and the stigmata, that caused a media storm. It includes a dream in which she makes love to a saint. The Vatican condemned the video. Family and religious groups protested it. Pepsi, which featured the song in a commercial, promptly dropped it and the singer.
In Gaga's video for her hit song "Alejandro," she swallows rosary beads while dressed as a nun in red latex, and simulates a sexual act while a crucifix stands nearby.
Some have called it homage to Madonna's "Like a Prayer" and "Vogue" videos; others say it's a rip-off.
Gaga has lashed out at those who accuse her of ripping off Madonna, most recently for her single "Born This Way," which has been compared to Madonna's "Express Yourself."
"That's retarded," she told NME. "If you put the songs next to each other, side by side, the only similarities are the chord progression. It's the same one that's been in disco music for the last 50 years. Just because I'm the first f***ing artist in 25 years to think of putting it on Top 40 radio, it doesn't mean I'm a plagiarist, it means I'm f***ing smart. Sorry."
Don't expect Gaga to apologize for being controversial.
"Everything that we're doing, the collaboration that I have with Lady Gaga, is shocking an inspirational and insightful and dynamic and electric!" Gibson told ABC News radio. "So we're not gonna stop anytime soon."
While Lady Gaga deals with the backlash on the "Judas" single, Weird Al Yankovic pays homage to Gaga in his parody, "Perform This Way."
Initially, the pop culture parodist was not going to put the parody song on his album without Gaga's approval.
But according to his blog post on Wednesday, it turns out Lady Gaga didn't know about the request.
"Gaga's manager has now admitted that he never forwarded my parody to Gaga – she had no idea at all. Even though we assumed that Gaga herself was the one making the decision (because, well, that's what we were TOLD), he apparently made the decision completely on his own. He's sorry. And Gaga loves the song," Yankovic wrote.
ABC News Radio's Andrea Dresdale contributed to this report.