After trying for so long to conceive, she was finally pregnant with daughter Coco when "Desperate Housewives" creator Marc Cherry wanted to cast her as Susan. The role went instead to Teri Hatcher.
A few years later, in 2007, she launched her comeback playing a tabloid editor in the FX sitcom "Dirt," which she and husband David Arquette produced. The show was canceled after the second season because of poor ratings. A long guest appearance on the NBC series "Scrubs" led to Cox's current role as a 40-something divorced real estate agent re-entering the dating scene in ABC's "Cougar Town."
"I think Courteney Cox is great at playing the comedy of discomfort," executive producer Bill Lawrence told ABCNews.com.
Lawrence, who also produced "Scrubs," approached Cox with the sitcom after he heard through the grapevine that she was looking to do comedy again. "She's a fearless comedian."
Apparently, the role couldn't have come at a better time. According to the Daily Mail, Cox had applied for a license to work as a real estate agent in real life too. With the series off to a good start, Cox has intimated that she'd like to have more children. "We're not trying yet. We're revving up the engines," she told OK magazine. "I'm only ready 'cause time's a-ticking."
In a recent interview with the Los Angeles Times, Cox said that she would love to reunite the "Friends" cast on the big screen, but is doubtful a movie would pan out.
"I wish we could do that with 'Friends,'" Cox said. "I don't think it's going to happen...a lot of things would have to break just right for it to work. But we've daydreamed about it."