"Your consciousness has to change and, I was very lucky and smart enough to realize that at that moment, it was life and death time, and movies, acting, dating, sports and everything just have to take a sideline to this," he told Film Monthly at the time.
Cox, 45, turned her focus to family following the end of "Friends."
After trying for so long to conceive, she was finally pregnant with daughter Coco when "Desperate Housewives" creator Marc Cherry wanted to cast her as Susan. The role went instead to Teri Hatcher.
A few years later, in 2007, she launched her comeback playing a tabloid editor in the FX sitcom "Dirt," which she and husband David Arquette produced. The show was canceled after the second season because of poor ratings. A long guest appearance on the NBC series "Scrubs" led to Cox's current role as a 40-something divorced real estate agent re-entering the dating scene in ABC's "Cougar Town."
"I think Courteney Cox is great at playing the comedy of discomfort," executive producer Bill Lawrence told ABCNews.com.
Lawrence, who also produced "Scrubs," approached Cox with the sitcom after he heard through the grapevine that she was looking to do comedy again. "She's a fearless comedian."
Apparently, the role couldn't have come at a better time. According to the Daily Mail, Cox had applied for a license to work as a real estate agent in real life too. With the series off to a good start, Cox has intimated that she'd like to have more children. "We're not trying yet. We're revving up the engines," she told OK magazine. "I'm only ready 'cause time's a-ticking."
In a recent interview with the Los Angeles Times, Cox said that she would love to reunite the "Friends" cast on the big screen, but is doubtful a movie would pan out.
"I wish we could do that with 'Friends,'" Cox said. "I don't think it's going to happen...a lot of things would have to break just right for it to work. But we've daydreamed about it."
After his ill-fated "Friends" spin-off "Joey" was cancelled after one season in 2006, LeBlanc, now 42, had few callers.
Four years later, he has finally landed a role on "Episodes," a new Showtime comedy series created by one of the producers of "Friends."
In the new series that spoofs the TV business, LeBlanc will play a version of himself.
"I am so glad I got the part," LeBlanc told The Hollywood Reporter. "Seeing someone else play Matt LeBlanc would have been devastating."
Even so, it hasn't been easy being LeBlanc lately. His marriage to British model Melissa McKnight failed around the time "Joey" did. According to People magazine, the couple was dealing with daughter Marina suffering seizures shortly after birth until she was 2. Then as the couple's third anniversary approached, LeBlanc suddenly moved out and began seeing his "Joey" co-star Andrea Anders. LeBlanc also made tabloid headlines after he admitted to groping a stripper at a Canadian nightclub.