"What seemed to matter was the length of time that women were exposed to hormone therapy," Sohrabji said. "The shorter that duration, the more likely they were to show dementia and movement disorders, and that's consistent with the idea that there's a critical period for hormone therapy. It also goes very well with data that recently emerged from the WHI regarding cardiovascular risk being much less in women who took estrogen earlier."
"All of these studies seem to be definitely pointing that there is a critical window for hormone therapy," she continued. "It speaks both to a critical [time] window and a critical duration."
Learn more about ovary removal from the Mayo Clinic.
SOURCES: Farida Sohrabji, Ph.D., associate professor, neuroscience and experimental therapeutics, Texas A&M Health Science Center College of Medicine; Aug. 29, 2007, Neurology, online