"There aren't a lot of questions about what steps make sense to controlling salmonella, it's just a matter of getting them in place," DeWaal added.
Each year, 76 million foodborne illnesses strike U.S. consumers, according to the latest data from the Centers for Disease Control and Prevention, including about 5,000 deaths.
Still, a recent study showed that many Americans ignore food recalls designed to keep them safe.
Eggs can appear perfectly fine to eat, but salmonella can result in gastrointestinal illness, arthritis, even death. The FDA said today that the new egg rule alone can prevent 79,000 illnesses and 30 deaths every year.
Today's rules call for egg producers with more than 3,000 hens to register with the FDA, follow new cleaning requirements to disinfect poultry houses and be subject to tighter inspections to safeguard against bacteria that may be carried by farm equipment and employees.
If inspectors find any four eggs laden with bacteria, egg producers will be required to do more processing to destroy it, or to use the eggs for a purpose other than food.
"We're putting a lot more focus now on the prevention side," Biden said.
The new rules also call for both pasteurized and unpasteurized eggs to be refrigerated at 45 degrees -- from 36 hours after they're laid until the time they're bought by shoppers.
Truck drivers, shippers and distributors will be called on to ensure eggs are refrigerated every step of the way and document it.
The major egg producers are required to make changes within the year. Farms with fewer than 50,000 hens will have three years to implement the changes.
"We want to cut down on that disease, and we can do it by putting in place simple, preventive measures and monitoring systems," Hamburg said. "And it's very cheap. It will only cost about one cent per dozen eggs you buy."
Multiple federal agencies will also collaborate on the other efforts announced today.
For instance, within the year, the Department of Agriculture's Food Safety and Inspection Service will hire more people to serve as liaisons with state public health departments. By month's end, the USDA will ask state and local agencies to update their emergency guidelines for handing outbreaks of food borne illnesses.
The CDC will also improve its system to gather data from states and share that information within the year.
Part of a stepped-up effort to keep shoppers informed about recalls will also be to improve the government Web site, www.foodsafety.gov.
The USDA said last summer it would start providing a list of all stores that received tainted beef or poultry within 10 days of issuing a recall.
ABC News' Olivia Hallihan, Devin Dwyer and Brian Hartman contributed to this report.