Overall, the study is unlikely to sway parents from using ART, Shevell said. Instead, it should help them understand the risks better.
"These complications had little impact on how the pregnancy fared. Having a C-section or high blood pressure during pregnancy didn't affect the babies' health or the families' quality of life. That's what we care most about," Shevell said.
For example, although she endured months of bed rest and invasive medical procedures, Margolis gave birth to a healthy baby boy. She and her husband are now the parents of a 3-year-old son, Nicholas, and have just welcomed 3-month-old twin girls to their family.
If she could go back in time, Margolis said the study's results about IVF would not change her mind.
"Absolutely not," she said. "It was all so worth it. The rewards so outweigh the risks."
Dr. Tracy Wimbush is an emergency physician at Massachusetts General Hospital in Boston.